Drug interactions
Ipratropium + Orphenadrine
Severity: Moderate
Ipratropium and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has substantial anticholinergic activity, so it can add to the effects of ipratropium and cause dry mouth, tachycardia, urinary retention, constipation and confusion. Older patients are at greater risk.
What this interaction means in plain words
Ipratropium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic effects and mental status changes, particularly in older adults. Avoid in patients with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Orphenadrine?
MediHelp rates the interaction as moderate. Ipratropium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has substantial anticholinergic activity, so it can add to the effects of ipratropium and cause dry mouth, tachycardia, urinary retention, constipation and confusion. Older patients are at greater risk.
How serious is the interaction between Ipratropium and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and mental status changes, particularly in older adults. Avoid in patients with glaucoma or urinary obstruction.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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