Drug interactions
Ipratropium + Protriptyline
Severity: Minor
Ipratropium and Protriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with strong anticholinergic activity, which can add to the effects of ipratropium. Systemic absorption of inhaled ipratropium is small, so clinically important additive effects are uncommon.
What this interaction means in plain words
Ipratropium and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects of the tricyclic with ipratropium.
What to do
Monitor for urinary retention, constipation, dry mouth and blurred vision, especially in older patients. Take extra care in patients with narrow-angle glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Protriptyline?
MediHelp rates the interaction as minor. Ipratropium and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Protriptyline is a tricyclic antidepressant with strong anticholinergic activity, which can add to the effects of ipratropium. Systemic absorption of inhaled ipratropium is small, so clinically important additive effects are uncommon.
How serious is the interaction between Ipratropium and Protriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, dry mouth and blurred vision, especially in older patients. Take extra care in patients with narrow-angle glaucoma or prostatic hypertrophy.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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