Drug interactions
Ipratropium + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Ipratropium and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is a long-acting antimuscarinic, so adding ipratropium duplicates anticholinergic therapy. This raises the risk of dry mouth, urinary retention, constipation, and possibly narrow-angle glaucoma worsening.
What this interaction means in plain words
Ipratropium and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism from two inhaled anticholinergics.
What to do
Avoid regular concurrent use and stop ipratropium when umeclidinium is started. Monitor for anticholinergic adverse effects if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Ipratropium and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is a long-acting antimuscarinic, so adding ipratropium duplicates anticholinergic therapy. This raises the risk of dry mouth, urinary retention, constipation, and possibly narrow-angle glaucoma worsening.
How serious is the interaction between Ipratropium and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use and stop ipratropium when umeclidinium is started. Monitor for anticholinergic adverse effects if combined.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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