Drug interactions
Ipratropium + Umeclidinium bromide
Severity: Moderate
Ipratropium and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled long- or short-acting muscarinic antagonists, and using them together duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention and worsening narrow-angle glaucoma.
What this interaction means in plain words
Ipratropium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate muscarinic receptor antagonism.
What to do
Avoid regular concurrent use; stop ipratropium when starting umeclidinium. Monitor for urinary retention and eye symptoms if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Ipratropium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled long- or short-acting muscarinic antagonists, and using them together duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention and worsening narrow-angle glaucoma.
How serious is the interaction between Ipratropium and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use; stop ipratropium when starting umeclidinium. Monitor for urinary retention and eye symptoms if both are used.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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