Drug interactions
Ipratropium-salbutamol + Lefamulin
Severity: Moderate
Ipratropium-salbutamol and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval, and salbutamol may add to this effect, especially with hypokalemia. Combined use may raise the risk of arrhythmia in patients with other QT risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Check potassium and consider ECG monitoring in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Lefamulin?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin prolongs the QT interval, and salbutamol may add to this effect, especially with hypokalemia. Combined use may raise the risk of arrhythmia in patients with other QT risk factors.
How serious is the interaction between Ipratropium-salbutamol and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and consider ECG monitoring in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective salbutamol dose.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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