Drug interactions
Ipratropium-salbutamol + Methadone
Severity: Moderate
Ipratropium-salbutamol and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is well known to prolong the QT interval and can cause torsades de pointes, and salbutamol may add risk through hypokalemia and tachycardia. Methadone also causes sedation and respiratory depression, which salbutamol does not offset and which are a concern in severe lung disease.
What this interaction means in plain words
Ipratropium-salbutamol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation with beta-2 agonist-related hypokalemia; methadone adds independent respiratory depression.
What to do
Check ECG, potassium and magnesium in patients on methadone who need frequent salbutamol, and correct deficits. Use the lowest effective salbutamol dose and monitor respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Methadone?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone is well known to prolong the QT interval and can cause torsades de pointes, and salbutamol may add risk through hypokalemia and tachycardia. Methadone also causes sedation and respiratory depression, which salbutamol does not offset and which are a concern in severe lung disease.
How serious is the interaction between Ipratropium-salbutamol and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium in patients on methadone who need frequent salbutamol, and correct deficits. Use the lowest effective salbutamol dose and monitor respiratory status.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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