Drug interactions
Ipratropium-salbutamol + Pasireotide
Severity: Moderate
Ipratropium-salbutamol and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and cause bradycardia. Salbutamol may add to arrhythmia risk through tachycardia and hypokalemia, mainly at high doses.
What this interaction means in plain words
Ipratropium-salbutamol and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a contributing factor.
What to do
Check ECG and correct potassium and magnesium abnormalities while on pasireotide. Avoid frequent high-dose salbutamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Pasireotide?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and cause bradycardia. Salbutamol may add to arrhythmia risk through tachycardia and hypokalemia, mainly at high doses.
How serious is the interaction between Ipratropium-salbutamol and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium abnormalities while on pasireotide. Avoid frequent high-dose salbutamol where possible.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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