Drug interactions
Ipratropium-salbutamol + Pazopanib
Severity: Moderate
Ipratropium-salbutamol and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and high doses of salbutamol can cause tachycardia and hypokalemia. Together they may increase arrhythmia risk, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Ipratropium-salbutamol and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a contributing factor.
What to do
Check ECG and electrolytes (potassium, magnesium) at baseline and periodically. Avoid excessive salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Pazopanib?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can prolong the QT interval and high doses of salbutamol can cause tachycardia and hypokalemia. Together they may increase arrhythmia risk, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Ipratropium-salbutamol and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes (potassium, magnesium) at baseline and periodically. Avoid excessive salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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