Drug interactions
Ipratropium-salbutamol + Pimavanserin
Severity: Moderate
Ipratropium-salbutamol and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin prolongs the QT interval and high-dose salbutamol can lower potassium and cause tachycardia. The combination may increase arrhythmia risk in predisposed patients.
What this interaction means in plain words
Ipratropium-salbutamol and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Check baseline ECG and electrolytes in patients with additional QT risk factors. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Pimavanserin?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin prolongs the QT interval and high-dose salbutamol can lower potassium and cause tachycardia. The combination may increase arrhythmia risk in predisposed patients.
How serious is the interaction between Ipratropium-salbutamol and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with additional QT risk factors. Avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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