Drug interactions
Ipratropium-salbutamol + Pitolisant
Severity: Moderate
Ipratropium-salbutamol and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval, and high-dose beta-2 agonists such as salbutamol may add to arrhythmia risk, in part through hypokalemia. The effect is greatest in patients with other QT risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and tachycardia adding to proarrhythmic risk.
What to do
Consider an ECG and check potassium and magnesium in patients with QT risk factors. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Pitolisant?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval, and high-dose beta-2 agonists such as salbutamol may add to arrhythmia risk, in part through hypokalemia. The effect is greatest in patients with other QT risk factors.
How serious is the interaction between Ipratropium-salbutamol and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and check potassium and magnesium in patients with QT risk factors. Avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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