Drug interactions
Ipratropium-salbutamol + Propranolol
Severity: Major
Ipratropium-salbutamol and Propranolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta-blocker that antagonizes salbutamol at beta-2 receptors, reducing bronchodilation and potentially causing bronchospasm in patients with asthma or COPD. This can make rescue inhalers ineffective.
What this interaction means in plain words
Ipratropium-salbutamol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ipratropium-salbutamol belongs to Respiratory; Propranolol belongs to Cardiovascular.
Why it happens
Competitive blockade of beta-2 adrenergic receptors opposes the effect of salbutamol.
What to do
Avoid non-selective beta-blockers in patients with asthma and use a cardioselective agent if a beta-blocker is essential. Monitor respiratory status and bronchodilator response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ipratropium-salbutamol
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Propranolol?
MediHelp rates the interaction as major. Ipratropium-salbutamol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta-blocker that antagonizes salbutamol at beta-2 receptors, reducing bronchodilation and potentially causing bronchospasm in patients with asthma or COPD. This can make rescue inhalers ineffective.
How serious is the interaction between Ipratropium-salbutamol and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with asthma and use a cardioselective agent if a beta-blocker is essential. Monitor respiratory status and bronchodilator response.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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