Drug interactions
Ipratropium-salbutamol + Quinine
Severity: Moderate
Ipratropium-salbutamol and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol and quinine can prolong the QT interval, and beta-agonist-induced hypokalemia may add to the arrhythmic risk. Systemic exposure to salbutamol from inhaled use is modest, so the effect is mostly relevant at high doses or in patients with other risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through pharmacodynamic effects, with beta-agonist-related hypokalemia as a contributing factor.
What to do
Obtain a baseline ECG and check potassium and magnesium in patients with additional QT risk factors or when high-dose salbutamol is used. Correct electrolyte abnormalities and avoid frequent or excessive salbutamol dosing during quinine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Quinine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol and quinine can prolong the QT interval, and beta-agonist-induced hypokalemia may add to the arrhythmic risk. Systemic exposure to salbutamol from inhaled use is modest, so the effect is mostly relevant at high doses or in patients with other risk factors.
How serious is the interaction between Ipratropium-salbutamol and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium and magnesium in patients with additional QT risk factors or when high-dose salbutamol is used. Correct electrolyte abnormalities and avoid frequent or excessive salbutamol dosing during quinine therapy.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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