Drug interactions
Ipratropium-salbutamol + Timolol
Severity: Major
Ipratropium-salbutamol and Timolol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is a non-selective beta-blocker that can antagonize salbutamol's bronchodilation and provoke bronchospasm in asthma or COPD, even with ophthalmic use in susceptible patients. Systemic absorption from eye drops is variable but clinically relevant.
What this interaction means in plain words
Ipratropium-salbutamol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ipratropium-salbutamol belongs to Respiratory; Timolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta2-adrenergic receptors.
What to do
Avoid timolol in patients with asthma or significant COPD and use an alternative such as a prostaglandin analogue for glaucoma. If unavoidable, monitor respiratory status and the response to salbutamol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ipratropium-salbutamol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Timolol?
MediHelp rates the interaction as major. Ipratropium-salbutamol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol is a non-selective beta-blocker that can antagonize salbutamol's bronchodilation and provoke bronchospasm in asthma or COPD, even with ophthalmic use in susceptible patients. Systemic absorption from eye drops is variable but clinically relevant.
How serious is the interaction between Ipratropium-salbutamol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid timolol in patients with asthma or significant COPD and use an alternative such as a prostaglandin analogue for glaucoma. If unavoidable, monitor respiratory status and the response to salbutamol.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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