Drug interactions
Irbesartan + Naproxen
Severity: Moderate
Irbesartan and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as naproxen can blunt the blood pressure lowering effect of angiotensin receptor blockers. In patients who are elderly, volume depleted or have existing renal impairment, the combination can also cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Irbesartan and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and sodium excretion, which opposes ARB effects and impairs glomerular perfusion when angiotensin II signaling is also blocked.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing the combination, and ensure adequate hydration. Use the lowest effective naproxen dose for the shortest time or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Naproxen?
MediHelp rates the interaction as moderate. Irbesartan and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as naproxen can blunt the blood pressure lowering effect of angiotensin receptor blockers. In patients who are elderly, volume depleted or have existing renal impairment, the combination can also cause acute kidney injury and hyperkalemia.
How serious is the interaction between Irbesartan and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing the combination, and ensure adequate hydration. Use the lowest effective naproxen dose for the shortest time or choose an alternative analgesic in high-risk patients.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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