Drug interactions
Irbesartan + Propranolol
Severity: Minor
Irbesartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two agents have additive blood pressure lowering, which is often therapeutically intended but may cause hypotension. Both can slightly raise potassium, beta-blockers by impaired cellular uptake and irbesartan by reduced aldosterone effect.
What this interaction means in plain words
Irbesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade and angiotensin receptor blockade, with minor additive effects on potassium.
What to do
Monitor blood pressure and, in renal impairment or with other potassium-raising drugs, serum potassium. Irbesartan should be avoided in pregnancy regardless of this combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irbesartan and Propranolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Propranolol?
MediHelp rates the interaction as minor. Irbesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two agents have additive blood pressure lowering, which is often therapeutically intended but may cause hypotension. Both can slightly raise potassium, beta-blockers by impaired cellular uptake and irbesartan by reduced aldosterone effect.
How serious is the interaction between Irbesartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and, in renal impairment or with other potassium-raising drugs, serum potassium. Irbesartan should be avoided in pregnancy regardless of this combination.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
