Drug interactions
Irbesartan + Siponimod
Severity: Minor
Irbesartan and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan is a CYP2C9 substrate with weak inhibitory activity at most, so any rise in siponimod exposure is likely small. The labeled concern applies to moderate CYP2C9 inhibitors combined with CYP3A4 inhibitors.
What this interaction means in plain words
Irbesartan and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Siponimod belongs to Central Nervous System.
Why it happens
Possible weak competition for CYP2C9, a main siponimod metabolic pathway.
What to do
No routine change is needed. Monitor heart rate and for siponimod adverse effects if other CYP2C9 or CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irbesartan and Siponimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Irbesartan with Siponimod?
MediHelp rates the interaction as minor. Irbesartan and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan is a CYP2C9 substrate with weak inhibitory activity at most, so any rise in siponimod exposure is likely small. The labeled concern applies to moderate CYP2C9 inhibitors combined with CYP3A4 inhibitors.
How serious is the interaction between Irbesartan and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor heart rate and for siponimod adverse effects if other CYP2C9 or CYP3A4 inhibitors are also used.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
