Drug interactions
Irbesartan + Tadalafil
Severity: Moderate
Irbesartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator and can add to the blood pressure lowering effect of angiotensin receptor blockers such as irbesartan. Symptomatic hypotension, dizziness or syncope may occur, particularly after the first doses or dose increases.
What this interaction means in plain words
Irbesartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation through PDE5 inhibition combined with angiotensin II receptor blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting tadalafil. Counsel the patient to rise slowly and consider a lower tadalafil starting dose in patients with unstable blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Tadalafil?
MediHelp rates the interaction as moderate. Irbesartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator and can add to the blood pressure lowering effect of angiotensin receptor blockers such as irbesartan. Symptomatic hypotension, dizziness or syncope may occur, particularly after the first doses or dose increases.
How serious is the interaction between Irbesartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting tadalafil. Counsel the patient to rise slowly and consider a lower tadalafil starting dose in patients with unstable blood pressure.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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