Drug interactions
Irbesartan + Timolol
Severity: Moderate
Irbesartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so combined use can produce additive hypotension. Angiotensin receptor blockers raise potassium, and beta-blockers may slightly impair potassium handling. Irbesartan is also contraindicated in pregnancy because of fetal toxicity, which is independent of timolol.
What this interaction means in plain words
Irbesartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, plus ARB-related potassium retention with minor beta-blocker contribution.
What to do
Monitor blood pressure and serum potassium, particularly in renal impairment or with other potassium-raising drugs. Confirm that women of childbearing potential are not pregnant and use effective contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Timolol?
MediHelp rates the interaction as moderate. Irbesartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so combined use can produce additive hypotension. Angiotensin receptor blockers raise potassium, and beta-blockers may slightly impair potassium handling. Irbesartan is also contraindicated in pregnancy because of fetal toxicity, which is independent of timolol.
How serious is the interaction between Irbesartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium, particularly in renal impairment or with other potassium-raising drugs. Confirm that women of childbearing potential are not pregnant and use effective contraception.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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