Drug interactions
Irbesartan + Tolmetin
Severity: Moderate
Irbesartan and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin can reduce the blood pressure lowering effect of irbesartan. Combined use can also cause acute kidney injury and hyperkalemia, especially in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Irbesartan and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAIDs block vasodilatory prostaglandins that maintain glomerular perfusion, while ARBs reduce efferent arteriolar tone, so renal filtration falls and potassium retention increases.
What to do
Monitor blood pressure, serum creatinine and potassium after starting and periodically thereafter. Maintain hydration and avoid the combination in patients with significant renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Tolmetin?
MediHelp rates the interaction as moderate. Irbesartan and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin can reduce the blood pressure lowering effect of irbesartan. Combined use can also cause acute kidney injury and hyperkalemia, especially in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Irbesartan and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting and periodically thereafter. Maintain hydration and avoid the combination in patients with significant renal impairment or volume depletion.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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