Drug interactions
Irbesartan + Tolvaptan
Severity: Minor
Irbesartan and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan does not typically cause hyperkalemia, though serum potassium can rise modestly in some patients. Combined with irbesartan, potassium should be watched. Both can contribute to volume depletion and hypotension.
What this interaction means in plain words
Irbesartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Irbesartan reduces renal potassium excretion while tolvaptan may cause small potassium increases and volume depletion; the potassium effect is not well established.
What to do
Monitor serum potassium and volume status when starting tolvaptan in patients taking irbesartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Irbesartan with Tolvaptan?
MediHelp rates the interaction as minor. Irbesartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan does not typically cause hyperkalemia, though serum potassium can rise modestly in some patients. Combined with irbesartan, potassium should be watched. Both can contribute to volume depletion and hypotension.
How serious is the interaction between Irbesartan and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and volume status when starting tolvaptan in patients taking irbesartan.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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