Drug interactions
Irinotecan + Lemborexant
Severity: Minor
Irinotecan and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a weak CYP2B6 inducer, and CYP2B6 plays only a minor role in irinotecan metabolism. Any change in irinotecan exposure is expected to be small.
What this interaction means in plain words
Irinotecan and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP2B6 induction by lemborexant may slightly increase irinotecan metabolism.
What to do
No dose adjustment is needed; monitor treatment response as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Irinotecan with Lemborexant?
MediHelp rates the interaction as minor. Irinotecan and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant is a weak CYP2B6 inducer, and CYP2B6 plays only a minor role in irinotecan metabolism. Any change in irinotecan exposure is expected to be small.
How serious is the interaction between Irinotecan and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor treatment response as routine.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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