Drug interactions
Irinotecan + Leniolisib
Severity: Moderate
Irinotecan and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may increase exposure to SN-38, a BCRP substrate. This could increase irinotecan toxicity such as diarrhoea and neutropenia.
What this interaction means in plain words
Irinotecan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Leniolisib belongs to Miscellaneous.
Why it happens
BCRP inhibition reduces efflux and biliary elimination of SN-38.
What to do
Monitor for neutropenia and diarrhoea and consider irinotecan dose adjustment if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Irinotecan with Leniolisib?
MediHelp rates the interaction as moderate. Irinotecan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and may increase exposure to SN-38, a BCRP substrate. This could increase irinotecan toxicity such as diarrhoea and neutropenia.
How serious is the interaction between Irinotecan and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neutropenia and diarrhoea and consider irinotecan dose adjustment if toxicity occurs.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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