Drug interactions
Irinotecan + Nicardipine
Severity: Moderate
Irinotecan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit P-glycoprotein and CYP3A4 and alter irinotecan and SN-38 disposition. Clinical significance is uncertain but toxicity such as diarrhea and neutropenia could theoretically increase.
What this interaction means in plain words
Irinotecan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of P-glycoprotein efflux and CYP3A4 metabolism of irinotecan by nicardipine.
What to do
Monitor for diarrhea and neutropenia during combined use. Manage toxicity per irinotecan protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Nicardipine?
MediHelp rates the interaction as moderate. Irinotecan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may inhibit P-glycoprotein and CYP3A4 and alter irinotecan and SN-38 disposition. Clinical significance is uncertain but toxicity such as diarrhea and neutropenia could theoretically increase.
How serious is the interaction between Irinotecan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia during combined use. Manage toxicity per irinotecan protocols.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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