Drug interactions
Irinotecan + Ticagrelor
Severity: Minor
Irinotecan and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and could modestly raise irinotecan exposure. The clinical effect is probably small, but irinotecan toxicity such as neutropenia and diarrhoea would be the concern. Thrombocytopenia from chemotherapy also raises bleeding risk with ticagrelor.
What this interaction means in plain words
Irinotecan and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor may reduce irinotecan clearance.
What to do
No routine dose change is required. Monitor for diarrhoea, neutropenia and bleeding, particularly if platelet counts fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Irinotecan with Ticagrelor?
MediHelp rates the interaction as minor. Irinotecan and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor and could modestly raise irinotecan exposure. The clinical effect is probably small, but irinotecan toxicity such as neutropenia and diarrhoea would be the concern. Thrombocytopenia from chemotherapy also raises bleeding risk with ticagrelor.
How serious is the interaction between Irinotecan and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for diarrhoea, neutropenia and bleeding, particularly if platelet counts fall.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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