Drug interactions
Irinotecan + Ustekinumab
Severity: Minor
Irinotecan and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is metabolized by CYP3A4 and UGT1A1, and its toxicity is substantial. Ustekinumab could theoretically alter CYP3A4 activity via cytokine changes, but no clinical effect is established.
What this interaction means in plain words
Irinotecan and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Theoretical normalization of cytokine-suppressed CYP3A4 activity.
What to do
Monitor for neutropenia and diarrhea as routine during irinotecan therapy, particularly when ustekinumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Ustekinumab?
MediHelp rates the interaction as minor. Irinotecan and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is metabolized by CYP3A4 and UGT1A1, and its toxicity is substantial. Ustekinumab could theoretically alter CYP3A4 activity via cytokine changes, but no clinical effect is established.
How serious is the interaction between Irinotecan and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neutropenia and diarrhea as routine during irinotecan therapy, particularly when ustekinumab is started or stopped.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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