Drug interactions
Irinotecan + Voxelotor
Severity: Moderate
Irinotecan and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can moderately inhibit CYP3A4 and raise concentrations of sensitive substrates. Irinotecan is metabolized by CYP3A4 and has a narrow therapeutic index, so higher exposure may increase diarrhea and neutropenia. Clinical data on this specific pair are lacking.
What this interaction means in plain words
Irinotecan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing the metabolic clearance of irinotecan.
What to do
Monitor for diarrhea and blood count suppression and consider an irinotecan dose reduction if the combination is needed. Prefer an alternative where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Irinotecan with Voxelotor?
MediHelp rates the interaction as moderate. Irinotecan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can moderately inhibit CYP3A4 and raise concentrations of sensitive substrates. Irinotecan is metabolized by CYP3A4 and has a narrow therapeutic index, so higher exposure may increase diarrhea and neutropenia. Clinical data on this specific pair are lacking.
How serious is the interaction between Irinotecan and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and blood count suppression and consider an irinotecan dose reduction if the combination is needed. Prefer an alternative where feasible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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