Drug interactions
Irinotecan liposomal + Itraconazole
Severity: Contraindicated
Irinotecan liposomal and Itraconazole: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise exposure to irinotecan and its active metabolite SN-38. This increases the risk of severe neutropenia and diarrhea.
What this interaction means in plain words
Irinotecan liposomal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition diverts irinotecan metabolism and raises SN-38 exposure.
What to do
Avoid during and for about two weeks after itraconazole. Use a non-CYP3A4-inhibiting antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Itraconazole?
MediHelp rates the interaction as contraindicated. Irinotecan liposomal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole may raise exposure to irinotecan and its active metabolite SN-38. This increases the risk of severe neutropenia and diarrhea.
How serious is the interaction between Irinotecan liposomal and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during and for about two weeks after itraconazole. Use a non-CYP3A4-inhibiting antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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