Drug interactions
Irinotecan liposomal + Sirolimus
Severity: Moderate
Irinotecan liposomal and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-gp and theoretically increase irinotecan exposure, although the clinical significance is unclear. Additive myelosuppression and mucosal toxicity from both drugs are also possible.
What this interaction means in plain words
Irinotecan liposomal and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible P-glycoprotein inhibition by sirolimus; additive myelosuppression is pharmacodynamic.
What to do
Monitor blood counts and diarrhea during combined therapy and reduce doses of irinotecan or sirolimus for significant toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Sirolimus?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may inhibit P-gp and theoretically increase irinotecan exposure, although the clinical significance is unclear. Additive myelosuppression and mucosal toxicity from both drugs are also possible.
How serious is the interaction between Irinotecan liposomal and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea during combined therapy and reduce doses of irinotecan or sirolimus for significant toxicity.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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