Drug interactions
Irinotecan liposomal + Voriconazole
Severity: Major
Irinotecan liposomal and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4, potentially increasing neutropenia and diarrhea.
What this interaction means in plain words
Irinotecan liposomal and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition reduces oxidative clearance of irinotecan, shifting metabolism and raising exposure to SN-38.
What to do
Avoid strong CYP3A4 inhibitors and use an alternative antifungal where possible. If necessary, monitor blood counts and diarrhea closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Voriconazole?
MediHelp rates the interaction as major. Irinotecan liposomal and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may increase exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4, potentially increasing neutropenia and diarrhea.
How serious is the interaction between Irinotecan liposomal and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors and use an alternative antifungal where possible. If necessary, monitor blood counts and diarrhea closely.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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