Drug interactions
Iron + Sarecycline
Severity: Moderate
Iron and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron can bind sarecycline in the gut and reduce its absorption, potentially weakening its antibacterial effect. The effect is predicted from the behavior of other tetracyclines.
What this interaction means in plain words
Iron and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of the tetracycline by polyvalent iron cations in the gastrointestinal tract reduces absorption.
What to do
Separate sarecycline and oral iron by at least 2 to 3 hours, giving sarecycline first where possible. Monitor acne response if iron therapy is needed long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Iron with Sarecycline?
MediHelp rates the interaction as moderate. Iron and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron can bind sarecycline in the gut and reduce its absorption, potentially weakening its antibacterial effect. The effect is predicted from the behavior of other tetracyclines.
How serious is the interaction between Iron and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline and oral iron by at least 2 to 3 hours, giving sarecycline first where possible. Monitor acne response if iron therapy is needed long term.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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