Drug interactions
Iron + Zinc
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Concurrent oral iron, especially at higher elemental doses, can reduce zinc absorption.
Mechanism of action
Competition for intestinal divalent metal transporters and formation of insoluble complexes reduces zinc uptake.
Clinical management
Administer iron and zinc at different times (separate by at least 2 hours). Consider monitoring zinc status during prolonged high-dose iron therapy.
Drug reference
References
- Zinc Fact Sheet for Health Professionals — NIH ODS
- Zinc Salts–Iron Salts drug interaction — Lexicomp
Frequently asked questions
Can I take Iron with Zinc?
The interaction is rated: Moderate. Concurrent oral iron, especially at higher elemental doses, can reduce zinc absorption.
How serious is the interaction between Iron and Zinc?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Iron and Zinc managed?
Administer iron and zinc at different times (separate by at least 2 hours). Consider monitoring zinc status during prolonged high-dose iron therapy.
Why do Iron and Zinc interact?
Competition for intestinal divalent metal transporters and formation of insoluble complexes reduces zinc uptake.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.