Drug interactions
Delafloxacin + Zinc
Severity: Moderate
Delafloxacin and Zinc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zinc binds oral delafloxacin in the gut and reduces its absorption, potentially causing subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Delafloxacin and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Zinc belongs to Gastrointestinal Tract.
Why it happens
Chelation of delafloxacin by polyvalent metal cations reduces gastrointestinal absorption.
What to do
Take delafloxacin at least 2 hours before or 6 hours after zinc products. Consider the intravenous formulation if separation is not possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Other interactions of Zinc
- Alendronate + Zinc Moderate
- Baloxavir marboxil + Zinc Moderate
- Cefalexin + Zinc Moderate
- Ciprofloxacin + Zinc Moderate
- Dolutegravir + Zinc Moderate
- Doxycycline + Zinc Moderate
Frequently asked questions
Can I take Delafloxacin with Zinc?
MediHelp rates the interaction as moderate. Delafloxacin and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zinc binds oral delafloxacin in the gut and reduces its absorption, potentially causing subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Delafloxacin and Zinc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take delafloxacin at least 2 hours before or 6 hours after zinc products. Consider the intravenous formulation if separation is not possible.
What other medicines interact with Delafloxacin?
MediHelp also lists interactions of Delafloxacin with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Delafloxacin page.
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