Drug interactions
Baloxavir marboxil + Zinc
Severity: Moderate
Baloxavir marboxil and Zinc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zinc supplements can bind baloxavir in the gut and reduce its absorption. This may lower antiviral concentrations and diminish efficacy against influenza.
What this interaction means in plain words
Baloxavir marboxil and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Zinc belongs to Gastrointestinal Tract.
Why it happens
Polyvalent zinc cations chelate baloxavir in the gastrointestinal tract, reducing absorption.
What to do
Avoid taking zinc-containing products with baloxavir and defer them until after the antiviral course where feasible. If they must be used, separate dosing as widely as practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baloxavir marboxil
- Aluminum hydroxide + Baloxavir marboxil Moderate
- Baloxavir marboxil + Calcium Moderate
- Baloxavir marboxil + Calcium carbonate Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Baloxavir marboxil + Ferrous fumarate Moderate
- Baloxavir marboxil + Ferrous gluconate Moderate
Other interactions of Zinc
- Alendronate + Zinc Moderate
- Cefalexin + Zinc Moderate
- Ciprofloxacin + Zinc Moderate
- Delafloxacin + Zinc Moderate
- Dolutegravir + Zinc Moderate
- Doxycycline + Zinc Moderate
Frequently asked questions
Can I take Baloxavir marboxil with Zinc?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zinc supplements can bind baloxavir in the gut and reduce its absorption. This may lower antiviral concentrations and diminish efficacy against influenza.
How serious is the interaction between Baloxavir marboxil and Zinc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking zinc-containing products with baloxavir and defer them until after the antiviral course where feasible. If they must be used, separate dosing as widely as practical.
What other medicines interact with Baloxavir marboxil?
MediHelp also lists interactions of Baloxavir marboxil with, for example, Aluminum hydroxide, Calcium, Calcium carbonate. The full list is on the Baloxavir marboxil page.
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