Drug interactions
Isavuconazole + Ketoconazole
Severity: Contraindicated
Isavuconazole and Ketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole strongly inhibits CYP3A4 and markedly increases isavuconazole exposure. This raises the risk of isavuconazole toxicity such as hepatic effects and QT shortening.
What this interaction means in plain words
Isavuconazole and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4/5, reducing isavuconazole clearance.
What to do
Avoid co-administration; use a single azole. If unavoidable, monitor liver function and isavuconazole-related adverse effects.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Isavuconazole with Ketoconazole?
MediHelp rates the interaction as contraindicated. Isavuconazole and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole strongly inhibits CYP3A4 and markedly increases isavuconazole exposure. This raises the risk of isavuconazole toxicity such as hepatic effects and QT shortening.
How serious is the interaction between Isavuconazole and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration; use a single azole. If unavoidable, monitor liver function and isavuconazole-related adverse effects.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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