Drug interactions
Isavuconazonium + Ketoconazole
Severity: Contraindicated
Isavuconazonium and Ketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
What this interaction means in plain words
Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4, the main enzyme clearing isavuconazole.
What to do
Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Ketoconazole?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
How serious is the interaction between Isavuconazonium and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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