Drug interactions
Isavuconazonium + Levonorgestrel
Severity: Minor
Isavuconazonium and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form, is a moderate CYP3A4 inhibitor and may modestly raise levonorgestrel concentrations. Clinically important harm is unlikely, though progestogenic adverse effects may be more noticeable.
What this interaction means in plain words
Isavuconazonium and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Levonorgestrel belongs to Endocrine.
Why it happens
Moderate CYP3A4 inhibition decreases levonorgestrel clearance.
What to do
No dose adjustment is usually needed; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Levonorgestrel?
MediHelp rates the interaction as minor. Isavuconazonium and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole, the active form, is a moderate CYP3A4 inhibitor and may modestly raise levonorgestrel concentrations. Clinically important harm is unlikely, though progestogenic adverse effects may be more noticeable.
How serious is the interaction between Isavuconazonium and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for progestogenic adverse effects.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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