Drug interactions
Isavuconazonium + Lidocaine
Severity: Minor
Isavuconazonium and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 substrate and is not a meaningful inhibitor, so a clinically relevant rise in isavuconazole levels is unlikely. The legacy direction of effect does not match established pharmacology. The reverse effect is also modest, since isavuconazole is only a moderate CYP3A4 inhibitor.
What this interaction means in plain words
Isavuconazonium and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Lidocaine belongs to Cardiovascular.
Why it happens
No meaningful lidocaine-mediated CYP3A4 inhibition is established; isavuconazole may weakly raise lidocaine exposure via CYP3A4 inhibition.
What to do
No action is needed for usual local anesthetic use. With high systemic lidocaine doses, monitor for toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Lidocaine?
MediHelp rates the interaction as minor. Isavuconazonium and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 substrate and is not a meaningful inhibitor, so a clinically relevant rise in isavuconazole levels is unlikely. The legacy direction of effect does not match established pharmacology. The reverse effect is also modest, since isavuconazole is only a moderate CYP3A4 inhibitor.
How serious is the interaction between Isavuconazonium and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for usual local anesthetic use. With high systemic lidocaine doses, monitor for toxicity.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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