Drug interactions
Isavuconazonium + Lorlatinib
Severity: Moderate
Isavuconazonium and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is metabolized by CYP3A4, and its exposure may fall when given with lorlatinib. Lower antifungal levels could lead to treatment failure in invasive fungal infection.
What this interaction means in plain words
Isavuconazonium and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, accelerating isavuconazole clearance.
What to do
Monitor clinical response to antifungal therapy and consider measuring isavuconazole concentrations. Raise the dose or change the antifungal if exposure proves inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Lorlatinib?
MediHelp rates the interaction as moderate. Isavuconazonium and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is metabolized by CYP3A4, and its exposure may fall when given with lorlatinib. Lower antifungal levels could lead to treatment failure in invasive fungal infection.
How serious is the interaction between Isavuconazonium and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider measuring isavuconazole concentrations. Raise the dose or change the antifungal if exposure proves inadequate.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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