Drug interactions
Isavuconazonium + Methadone
Severity: Moderate
Isavuconazonium and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and can raise methadone concentrations. Methadone is not expected to meaningfully change isavuconazole levels, and the main concern is increased opioid effect and QT prolongation.
What this interaction means in plain words
Isavuconazonium and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Methadone belongs to Musculoskeletal.
Why it happens
Isavuconazole inhibits CYP3A4, decreasing methadone clearance, and it also shortens QT interval slightly.
What to do
Monitor for sedation and respiratory depression when starting isavuconazonium, and consider lowering the methadone dose if needed. Monitor the ECG in patients with other QT risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Methadone?
MediHelp rates the interaction as moderate. Isavuconazonium and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and can raise methadone concentrations. Methadone is not expected to meaningfully change isavuconazole levels, and the main concern is increased opioid effect and QT prolongation.
How serious is the interaction between Isavuconazonium and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression when starting isavuconazonium, and consider lowering the methadone dose if needed. Monitor the ECG in patients with other QT risks.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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