Drug interactions
Isavuconazonium + Nifedipine
Severity: Moderate
Isavuconazonium and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise nifedipine concentrations, increasing hypotension, flushing and edema. Nifedipine is not a meaningful inhibitor of isavuconazole metabolism.
What this interaction means in plain words
Isavuconazonium and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Nifedipine belongs to Cardiovascular.
Why it happens
Isavuconazole inhibits CYP3A4, reducing nifedipine metabolism.
What to do
Monitor blood pressure and edema when starting isavuconazonium and reduce the nifedipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Nifedipine?
MediHelp rates the interaction as moderate. Isavuconazonium and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise nifedipine concentrations, increasing hypotension, flushing and edema. Nifedipine is not a meaningful inhibitor of isavuconazole metabolism.
How serious is the interaction between Isavuconazonium and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when starting isavuconazonium and reduce the nifedipine dose if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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