Drug interactions
Isavuconazonium + Nilotinib
Severity: Moderate
Isavuconazonium and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and moderate inhibitor, so the two drugs can raise each other's exposure. Higher nilotinib levels increase QT prolongation risk, though isavuconazole itself shortens the QT interval.
What this interaction means in plain words
Isavuconazonium and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Nilotinib belongs to Oncology.
Why it happens
Isavuconazole inhibits CYP3A4, reducing nilotinib clearance; nilotinib may modestly raise isavuconazole levels.
What to do
Monitor the ECG and electrolytes, and consider reducing nilotinib dose if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Nilotinib?
MediHelp rates the interaction as moderate. Isavuconazonium and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate and moderate inhibitor, so the two drugs can raise each other's exposure. Higher nilotinib levels increase QT prolongation risk, though isavuconazole itself shortens the QT interval.
How serious is the interaction between Isavuconazonium and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, and consider reducing nilotinib dose if QTc lengthens.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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