Drug interactions
Isavuconazonium + Oxybutynin
Severity: Moderate
Isavuconazonium and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise oxybutynin exposure. Higher levels may intensify anticholinergic adverse effects. The legacy direction of the interaction is reversed, as oxybutynin is the substrate.
What this interaction means in plain words
Isavuconazonium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Oxybutynin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated metabolism of oxybutynin by isavuconazole.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation, confusion and urinary retention, and reduce the oxybutynin dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isavuconazonium and Oxybutynin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxybutynin
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Oxybutynin?
MediHelp rates the interaction as moderate. Isavuconazonium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise oxybutynin exposure. Higher levels may intensify anticholinergic adverse effects. The legacy direction of the interaction is reversed, as oxybutynin is the substrate.
How serious is the interaction between Isavuconazonium and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation, confusion and urinary retention, and reduce the oxybutynin dose if they occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
