Drug interactions
Isavuconazonium + Quinine
Severity: Moderate
Isavuconazonium and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, inhibits CYP3A4 and P-glycoprotein and can raise quinine concentrations. Quinine may in turn modestly raise isavuconazole exposure through CYP3A4 effects. Higher quinine levels increase the risk of cinchonism and QT prolongation.
What this interaction means in plain words
Isavuconazonium and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Quinine belongs to Anti Parasitic.
Why it happens
Isavuconazole inhibits CYP3A4 and P-gp, reducing quinine clearance; quinine may weakly inhibit CYP3A4 metabolism of isavuconazole.
What to do
Monitor for quinine toxicity (tinnitus, visual disturbance, arrhythmia) and consider an ECG if therapy is prolonged. Reduce the quinine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Quinine?
MediHelp rates the interaction as moderate. Isavuconazonium and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety of isavuconazonium, inhibits CYP3A4 and P-glycoprotein and can raise quinine concentrations. Quinine may in turn modestly raise isavuconazole exposure through CYP3A4 effects. Higher quinine levels increase the risk of cinchonism and QT prolongation.
How serious is the interaction between Isavuconazonium and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity (tinnitus, visual disturbance, arrhythmia) and consider an ECG if therapy is prolonged. Reduce the quinine dose if adverse effects appear.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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