Drug interactions
Isavuconazonium + Tamoxifen
Severity: Minor
Isavuconazonium and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and tamoxifen is a weak CYP3A4 inhibitor, so isavuconazole concentrations could rise slightly. Clinical significance is probably small.
What this interaction means in plain words
Isavuconazonium and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Tamoxifen belongs to Endocrine.
Why it happens
Tamoxifen weakly inhibits CYP3A4 metabolism of isavuconazole.
What to do
No dose change is needed; monitor for azole adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Tamoxifen?
MediHelp rates the interaction as minor. Isavuconazonium and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and tamoxifen is a weak CYP3A4 inhibitor, so isavuconazole concentrations could rise slightly. Clinical significance is probably small.
How serious is the interaction between Isavuconazonium and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for azole adverse effects such as liver enzyme elevation.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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