Drug interactions
Isavuconazonium + Triamcinolone
Severity: Moderate
Isavuconazonium and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form of isavuconazonium, is a moderate CYP3A4 inhibitor and may raise triamcinolone levels, increasing systemic corticosteroid effects and adrenal suppression. Corticosteroid immunosuppression also adds to infection risk in patients treated for fungal infection.
What this interaction means in plain words
Isavuconazonium and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Triamcinolone belongs to Endocrine.
Why it happens
Isavuconazole inhibits CYP3A4, reducing triamcinolone clearance, and corticosteroids add pharmacodynamic immunosuppression.
What to do
Monitor for Cushingoid effects and adrenal suppression with repeated triamcinolone dosing. Consider an alternative corticosteroid if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Triamcinolone?
MediHelp rates the interaction as moderate. Isavuconazonium and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active form of isavuconazonium, is a moderate CYP3A4 inhibitor and may raise triamcinolone levels, increasing systemic corticosteroid effects and adrenal suppression. Corticosteroid immunosuppression also adds to infection risk in patients treated for fungal infection.
How serious is the interaction between Isavuconazonium and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid effects and adrenal suppression with repeated triamcinolone dosing. Consider an alternative corticosteroid if prolonged therapy is needed.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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