Drug interactions
Isavuconazonium + Vinorelbine
Severity: Moderate
Isavuconazonium and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor, so it may raise vinorelbine exposure, rather than the reverse. This could increase neutropenia and neurotoxicity.
What this interaction means in plain words
Isavuconazonium and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Vinorelbine belongs to Oncology.
Why it happens
Isavuconazole inhibits CYP3A4 and may reduce vinorelbine clearance.
What to do
Monitor blood counts and neurotoxicity closely. Reduce the vinorelbine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Vinorelbine?
MediHelp rates the interaction as moderate. Isavuconazonium and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor, so it may raise vinorelbine exposure, rather than the reverse. This could increase neutropenia and neurotoxicity.
How serious is the interaction between Isavuconazonium and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity closely. Reduce the vinorelbine dose if toxicity appears.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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