Drug interactions
Isocarboxazid + Linagliptin-metformin
Severity: Moderate
Isocarboxazid and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The effect on metformin specifically is not well characterized.
What this interaction means in plain words
Isocarboxazid and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity; the exact mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the MAO inhibitor. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Isocarboxazid and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The effect on metformin specifically is not well characterized.
How serious is the interaction between Isocarboxazid and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the MAO inhibitor. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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