Drug interactions
Isocarboxazid + Linezolid
Severity: Contraindicated
Isocarboxazid and Linezolid: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit monoamine oxidase, so combining them risks serotonin syndrome and hypertensive reactions. Isocarboxazid is an irreversible MAOI, making the effect prolonged.
What this interaction means in plain words
Isocarboxazid and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive inhibition of monoamine oxidase leading to excess serotonin and catecholamines.
What to do
Do not combine; use a non-MAOI antibiotic. Wait for the MAOI washout of about two weeks before starting linezolid unless urgent treatment is needed under close monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Linezolid?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs inhibit monoamine oxidase, so combining them risks serotonin syndrome and hypertensive reactions. Isocarboxazid is an irreversible MAOI, making the effect prolonged.
How serious is the interaction between Isocarboxazid and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-MAOI antibiotic. Wait for the MAOI washout of about two weeks before starting linezolid unless urgent treatment is needed under close monitoring.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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