Drug interactions
Isocarboxazid + Methohexital
Severity: Major
Isocarboxazid and Methohexital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may prolong and intensify the effects of barbiturate anesthetics and sedatives. This can cause excessive sedation, respiratory depression and hypotension.
What this interaction means in plain words
Isocarboxazid and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible reduced barbiturate metabolism by MAO inhibitors.
What to do
If anesthesia is needed, inform the anesthesiologist and use reduced doses with close monitoring of respiration and blood pressure. Avoid routine concomitant use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Isocarboxazid with Methohexital?
MediHelp rates the interaction as major. Isocarboxazid and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors may prolong and intensify the effects of barbiturate anesthetics and sedatives. This can cause excessive sedation, respiratory depression and hypotension.
How serious is the interaction between Isocarboxazid and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If anesthesia is needed, inform the anesthesiologist and use reduced doses with close monitoring of respiration and blood pressure. Avoid routine concomitant use.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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