Drug interactions
Isocarboxazid + Saxagliptin-metformin
Severity: Moderate
Isocarboxazid and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and may cause hypoglycemia. The effect is variable and mainly documented with insulin and sulfonylureas.
What this interaction means in plain words
Isocarboxazid and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
MAO inhibition may increase insulin sensitivity and insulin secretion, adding to antidiabetic effects.
What to do
Monitor blood glucose when starting or stopping isocarboxazid and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Isocarboxazid and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and may cause hypoglycemia. The effect is variable and mainly documented with insulin and sulfonylureas.
How serious is the interaction between Isocarboxazid and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping isocarboxazid and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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